Virtual human physiology simulation has the potential to transform medical education through high-fidelity simulations and models. We are developing innovative medical education tools driven by a physiology engine to teach complex physiological concepts in cardiovascular and respiratory systems. This tool enables students to understand cardiovascular and respiratory physiology through visualization, interactive learning, and comparison. We have modelled four valvular defect scenarios namely: Aortic Stenosis, Aortic Regurgitation, Mitral Valve Stenosis, and Mitral Valve Regurgitation in BioGears physiology engine. BioGears is a C++ based virtual physiology engine that enables accurate and consistent physiology simulations. Similarly, we are developing modules for the respiratory system that include simulations for obstructive and restrictive lung diseases. We are collaborating with medical curriculum directors from the University of Illinois College of Medicine, Peoria to develop these education modules. Using virtual physiology based curriculum facilitates in-depth understanding of fundamental physiological concepts and develops a strong core of scientific understanding of the human body.