OxiplexTS200, a Non-invasive Absolute Tissue Oximeter for Measurements in the Muscle and the Brain

barbieriBeniamino Barbieri

President, ISS

kOxiplexTS200 is a noninvasive tissue oximeter for the measurement of the absolute concentrations of oxy- and deoxy-hemoglobin in tissues (muscle and brain); from these parameters, the instrument determines the total hemoglobin content and the oxygen saturation of the tissue. The determination of the hemodynamic parameters is based on real-time measurement of the optical properties of the tissue. Unlike other commercial devices that make longitudinal assumptions on the optical properties of the tissues, OxiplexTS200 measures the actual parameters in each subject, and therefore provides a measurement specific to the subject. The underlying algorithm used by the instrument (frequency-domain multi-distance) has been developed by researchers at the University of Illinois and is covered by intellectual property agreements. Applications include ones related to peripheral vascular disease, sleep apnea, brain oxygenation monitoring, and sports medicine.


  1. Fantini, M. A. Franceschini, J. S. Maier, S.A. Walker, B. Barbieri, and E. Gratton: “Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry,” Opt. Engineering 34, pp. 32-42 (1995).
  2. Michalos, L. P. Safonova, U. Wolf, M. Wolf, J. H. Choi, R. Gupta, W. W. Mantulin, D. M. Hueber, B. Barbieri, and E. Gratton. Obstructive Sleep Apnea; “Evaluation of brain oxygenation and hemodynamics by near-infrared spectroscopy,” SLEEP 25 (suppl): 547.R, A390-391 (2002).



Beniamino Barbieri is the President and CEO of ISS in Champaign, Illinois. He holds a degree in Physics from the University of Pisa, Italy, and joined ISS in 1986. ISS’s mission encompasses the development and design of highly sensitive scientific instrumentation for research, clinical, and industrial applications based upon fluorescence. ISS has a long history of innovation and holds patents pertinent to frequency-domain instrumentation. A second product line includes near-infrared instrumentation for medical applications. ISS instruments are installed in universities and corporations worldwide. The customer list includes several major universities, corporations, hospitals, and research institutions across the globe, including (in the United States) the Mayo Foundation, the VA Administration, the National Institute of Standards and Technology, the National Institutes of Health, Oak Ridge National Laboratories, and the National Aeronautics and Space Administration (NASA).